Batch Harbinger: Born to Jump, Built to Cut, Made to Change

by: Christine Grace Sibayan (Harbinger)



    Harbinger represents a diverse superfamily of DNA transposons —often called “jumping genes”—found across various species, including protists, plants, insects, worms, and vertebrates. These mobile genetic elements played a significant role in genome evolution because of their ability to induce mutations by creating duplicate genes. Harbinger transposons operate through a “cut-and-paste” mechanism and preferentially target a specific 15-base pair consensus sequence when integrating themselves into new genomic sites. They require two helper proteins to work: a transposase that cuts and binds the DNA and a DNA-binding protein that helps find a new location.

    

    Just as Harbinger transposons relocate within a genome, Batch Harbinger also moves through different roles and phases in their lives. Each move resulted in new connections and possibilities that helped them to unlock potentials. The members are all from Batch 2024: Miggy from BS Agricultural Biotechnology, Kei and Eco from BS Nutrition, and Tin from BS Biology. Comparable to the crucial elements and features of Harbinger transposons, the combined experiences, skills, and perspectives of these four members can lead to unique insights and innovations that would be impossible to achieve individually. 


Christine Grace “Tin” Sibayan 

    Aside from her excellence in handling microscopes and unraveling scientific mysteries, Tin never fails to exude her entertaining wit and warm personality. With her pleasing voice, warm smile, and wonderful charm, Tin is an undeniable force of good influence from the first time you talk with her—well, actually, maybe when she talks to you first! She is the chief of the bounty who embodies leadership and scientific passion in everything she does. Her ability to balance serious work with lighthearted moments creates the perfect environment for everyone to thrive.


Yuan Miguel “Miggy” Jose

    Miggy is an amazing student leader and is like the busy bee of the batch. Even though his schedule is always filled with important responsibilities, he never fails to miss any batch meeting. Miggy is a very well-spoken person that sometimes you’ll wonder if he has a premade script in his mind! His words are clear and thoughtful, and he always knows exactly what to say in any situation. The best thing about having him in our batch is how much he knows. He definitely adds important information whenever we’re doing our tasks, helping us do better work. Miggy is outgoing and friendly too, making everyone feel welcome. He’s the kind of person who makes hard work seem fun, and it motivates the whole team to do the same. 


Keira Maxine “Kei” Reyes

    Kei is the real definition of a happy sunshine — cheerful, bright, and knows where she’s going. When she has a goal, she focuses straight on it like a superhero on a mission. One special thing about Kei is that she never, ever gives up! She sticks all the way to the end of anything she starts and plans. Something even more interesting about her is that she becomes a dancing star when music plays; you should definitely see her dancing on stage someday! On top of all that, Kei brings so much value to the group academically — she's sharp, insightful, and always ready to help others understand and learn.


Andrei Enrico “Eco” San Diego

    Eco is similar to a shy little puzzle piece at first. He initially presents himself with quiet reserve among the batch. But guess what? Under his thoughtful silence is the remarkable intelligence he brings to every task. He may seem withdrawn at first, but Eco slowly unfolds his personality as comfort and familiarity set in, and then he starts to share all his cool ideas and contributions that prove invaluable to the group dynamic. His adaptability mirrors the precision of molecular integration — when faced with challenges, he just figures out a new way to solve the problem. That's what makes him such an awesome friend to have on the team. Maybe it’s the BS Nutrition freshman in him, but even though he's quiet, his brain is always cooking up something amazing!



SOURCES

Kapitonov, V. V., & Jurka, J. (2004). Harbinger transposons and an ancient HARBI1 gene derived from a transposase. DNA and cell biology, 23(5), 311–324. https://doi.org/10.1089/104454904323090949 

Sinzelle, L., Kapitonov, V. V., Grzela, D. P., Jursch, T., Jurka, J., Izsvák, Z., & Ivics, Z. (2008). Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. Proceedings of the National Academy of Sciences of the United States of America, 105(12), 4715–4720. https://doi.org/10.1073/pnas.0707746105 


This article was originally published in the GENEWS May 2025 Issue.

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